The inability to raise money has been impeded by government red tape, according to a number of British organisations.
The charities, together with the People's Postcode Lottery, have begged the UK Government to end 'pointless and outmoded' limits on charity fundraising, which are predicted to cost them $194 million ($249 million) over the following five years.
One of the impacted organisations, The Royal Voluntary Service, estimates a loss of up to £5.3 million.
"The support of the People's Postcode Lottery players has a monumental impact on the services that we deliver to support the health and wellbeing of some of the most vulnerable people in our communities," said Catherine Johnstone CBE, Chief Executive of Royal Voluntary Service.
The Royal Voluntary Service can activate its volunteers to reach and serve over 60,000 individuals in person and close to 50,000 people digitally around the UK due to players.
Other impacted charities are Maggie's, Barnardo's, Young Lives v Cancer, and Barnardo's, two groups that help cancer patients, which are each estimated to lose up to £4.3 million. Barnardo's, which might lose up to £5.1 million, is also among them.
"Over the last 15 years, funding from players of the People's Postcode Lottery has helped transform the support we have been able to provide, helping us extend our network of cancer support centres and reach many more people with cancer as well as their families and friends," said Dame Laura Lee DBE, Maggie's Chief Executive.